Compound
Semaglutide
Everything in the archive that discusses Semaglutide in substance — with sources and context.
4 matching articles
Research · 5 September 2026 · 10 min read
Semaglutide vs Tirzepatide: What the Head-to-Head Trial Evidence Actually Shows
Two approved incretin medicines, one direct comparison trial and a great deal of confusion in between. A source-checked reading of STEP 1, SURMOUNT-1, SURPASS-2 and the open-label SURMOUNT-5 comparison.
Longevity · 31 August 2026 · 6 min read
Preserving Lean Mass During GLP-1 Receptor Agonist Protocols: Physiology and Nutritional Countermeasures
Rapid body weight reduction induced by GLP-1 receptor agonists presents a major clinical challenge: preventing disproportionate lean mass loss. We review the physiological mechanisms and dietary strategies required to preserve skeletal muscle integrity.
Profiles · 31 August 2026 · 5 min read
Paradigm Shifts in Metabolic Pharmacotherapy: Deconstructing the GLP-1 Public Narrative
High-profile public discussions surrounding GLP-1 receptor agonists have reframed metabolic management from a narrative of willpower to one of central neuroendocrine regulation. We analyze the scientific mechanics behind this shift.
Research · 31 August 2026 · 14 min read
What Is Retatrutide? Mechanism, Phase 3 Results and Approval Status
Retatrutide (LY3437943) is an investigational triple hormone receptor agonist at the GIP, GLP-1 and glucagon receptors. What the peer-reviewed trials show, how the 2026 topline Phase 3 results should be read, and why it is approved nowhere.